Core Technology PICT
Bottlenecks in Peptide Drug Development
It has a short half-life and is not easily administered orally.
1. Prone to enzymatic degradation, oxidation, and hydrolysis; exhibits poor stability.
2. High renal clearance
3. Prone to aggregation and precipitation
4. Low cell membrane permeability
- Peptide Synthesis Chemistry
- Peptide Medicinal Chemistry
- Peptide formulations and delivery optimization
- Structural biology, computational chemistry
1. Cyclic structure
2. Amino-terminal methylation
3. Introduction of non-natural or D‑configured amino acids
4. Fatty acidylation, PEGylation, and fusion proteins
5. Optimization of drug delivery systems: liposomes, nanoparticles, microspheres, etc.
There is a scarcity of sources for peptide-based bioactive molecules.
1. Endogenous peptides/natural bioactive peptides
2. Chemically Synthesized Peptides
3. Phage-display peptide library/mRNA-display peptide library/DNA-encoded peptide library/virtual peptide library
- Limited quantity; difficult to isolate, identify, and synthesize.
- Small storage capacity and insufficient diversity; high costs and time-consuming.
- Compound library; large library capacity; screening methods with limited target scope; high false-positive and false-negative rates.
PICT technology
Comparative Analysis of Similar Technologies
The process of discovering bioactive molecules using a comprehensive peptide library.
The Process of Innovative Peptide Drug Development
Empowering the thriving development of peptide therapeutics worldwide, enabling cost‑effective access to peptide medicines for patients around the globe, and contributing to human health.
Hunan Zhongsheng Quanpeptide Biotechnology Co., Ltd.
Contact Information
Email:info@peplib.com
Company Address: Building 5, Modern Service Industry Headquarters Park, No. 1769 Yunlong Avenue, Yunlong Demonstration Zone, Zhuzhou, Hunan Province
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